Regulation of JUN kinase activity

Across TCGA cell cohorts, RNA activity of the Regulation of JUN kinase activity pathway is significantly associated with the RNA expression of multiple genes, with the BLOOD_Lymphoma cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are NCEH1, TLCD4, and NFIL3, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of JUN kinase activity activity versus NCEH1 in BLOOD_Lymphoma (Pearson r = -0.49).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Lymphoma	NCEH1 →	-1.606	-0.342	<.001	.002	3	5
BLOOD_Lymphoma	TLCD4 →	-1.627	-0.279	.001	.001	3	5
BLOOD_Lymphoma	NFIL3 →	-2.618	-0.269	.003	.002	3	5
BONE	MME →	-5.152	-1.454	.001	<.001	3	4
BLOOD_Leukemia	HAGH →	-0.816	-0.275	.001	<.001	3	4
BLOOD_Lymphoma	AAK1 →	-2.079	-0.268	<.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0043506 vs NCEH1 — BLOOD_Lymphoma

Explore this scatter interactively →