Mitochondrial DNA repair

Across TCGA patient cohorts, RNA activity of the Mitochondrial DNA repair pathway is significantly associated with the protein abundance of multiple proteins, with the PDAC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are RFC5, CDK1, and RFC4, each associated with the pathway in up to 10 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Mitochondrial DNA repair activity versus RFC5 in PDAC (Pearson r = 0.15).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
PDAC	RFC5 →	+0.251	+0.060	.002	<.001	3	9
LUAD	CDK1 →	+0.662	+0.055	<.001	<.001	3	9
PDAC	RFC4 →	+0.283	+0.046	.007	.004	2	10
PDAC	RFC2 →	+0.326	+0.055	<.001	<.001	3	9
PDAC	MCM6 →	+0.635	+0.065	<.001	<.001	3	8
GBM	NASP →	+0.593	+0.067	.002	.003	3	8

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0043504 vs RFC5 — PDAC

Explore this scatter interactively →