Regulation of RNA splicing

Across TCGA cell cohorts, RNA activity of the Regulation of RNA splicing pathway is significantly associated with the shRNA dependency of multiple genes, with the SOFT_TISSUE cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are OR2H1, LRP11, and SIAH3, each associated with the pathway in up to 8 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, OR2H1 grouped by Regulation of RNA splicing-low versus -high activity in SOFT_TISSUE.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SOFT_TISSUE	OR2H1 →	+0.307	+0.137	.002	.003	3	8
CNS	LRP11 →	+0.281	+0.202	<.001	<.001	3	7
BLOOD_Leukemia	SIAH3 →	+0.259	+0.241	.006	.002	3	7
LUNG_NSCLC_LUSC	SLC25A1 →	+0.424	+0.184	.001	.004	3	7
BLOOD_Lymphoma	ANO1 →	+0.459	+0.240	.006	.008	2	7
BLOOD_Leukemia	ACCS →	+0.240	+0.230	.002	.001	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

OR2H1 by Regulation of RNA splicing activity — SOFT_TISSUE

Explore this box plot interactively →