Regulation of RNA splicing

Across TCGA cell cohorts, RNA activity of the Regulation of RNA splicing pathway is significantly associated with the RNA expression of multiple genes, with the STOMACH cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are ILF3, CAD, and KHDRBS1, each associated with the pathway in up to 8 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of RNA splicing activity versus ILF3 in STOMACH (Pearson r = 0.54).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
STOMACH	ILF3 →	+0.949	+0.179	.001	.003	3	8
BREAST	CAD →	+0.777	+0.163	.006	<.001	3	7
OVARY	KHDRBS1 →	+0.624	+0.209	<.001	<.001	3	7
OVARY	RBMX →	+0.507	+0.145	<.001	.001	3	7
OVARY	KIAA1586 →	+1.318	+0.253	<.001	.001	3	7
OVARY	PRR3 →	+1.182	+0.220	<.001	<.001	3	7

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0043484 vs ILF3 — STOMACH

Explore this scatter interactively →