Regulation of cellular respiration

Across TCGA patient cohorts, RNA activity of the Regulation of cellular respiration pathway is significantly associated with the RNA expression of multiple genes, with the COAD cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are CCDC102B, TRBV5-7, and SOAT1, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of cellular respiration activity versus CCDC102B in COAD (Pearson r = -0.18).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	CCDC102B →	-0.479	-0.130	.001	.001	3	4
PDAC	TRBV5-7 →	-0.886	-0.118	.003	.004	3	4
PDAC	SOAT1 →	-0.296	-0.121	.002	.003	3	4
LSCC	CNN3 →	-0.344	-0.094	.006	<.001	3	4
CCRCC	MYCT1 →	-0.702	-0.098	.004	.002	3	4
CCRCC	NKILA →	-0.320	-0.072	.003	.003	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0043457 vs CCDC102B — COAD

Explore this scatter interactively →