Regulation of pentose-phosphate shunt

Across TCGA cell cohorts, RNA activity of the Regulation of pentose-phosphate shunt pathway is significantly associated with the RNA expression of multiple genes, with the SKIN cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are CDKN1A, FDXR, and DDB2, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, CDKN1A grouped by Regulation of pentose-phosphate shunt-low versus -high activity in SKIN.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKIN	CDKN1A →	-2.747	-1.234	<.001	<.001	3	5
SKIN	FDXR →	-1.690	-1.741	<.001	<.001	3	5
OVARY	DDB2 →	-1.316	-0.842	<.001	.009	3	5
LUNG_NSCLC_LUAD	GNB1L →	+0.708	+0.665	.003	.006	3	4
BLOOD_Lymphoma	STAT5A →	+4.217	+0.359	.001	.002	3	4
LUNG_SCLC	ZNF665 →	+1.498	+0.344	.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

CDKN1A by Regulation of pentose-phosphate shunt activity — SKIN

Explore this box plot interactively →