Regulation of secondary metabolic process

Across TCGA patient cohorts, RNA activity of the Regulation of secondary metabolic process pathway is significantly associated with the RNA expression of multiple genes, with the HNSC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are P2RY14, AHI1, and RASSF6, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of secondary metabolic process activity versus P2RY14 in HNSC (Pearson r = -0.26).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
HNSC	P2RY14 →	-0.758	-0.304	<.001	<.001	3	4
LSCC	AHI1 →	-0.592	-0.645	.001	.001	3	3
BRCA	RASSF6 →	-0.951	-0.391	<.001	.003	3	3
HNSC	BCL2 →	-0.744	-0.348	.002	.002	3	3
BRCA	GPR171 →	-0.784	-0.382	.005	.002	3	3
LSCC	KLHL32 →	-0.366	-0.403	.005	.002	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0043455 vs P2RY14 — HNSC

Explore this scatter interactively →