Regulation of secondary metabolic process

Across TCGA cell cohorts, RNA activity of the Regulation of secondary metabolic process pathway is significantly associated with the RNA expression of multiple genes, with the LUNG_NSCLC_LUAD cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are MRPS9, SGPP1, and TIMM9, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, MRPS9 grouped by Regulation of secondary metabolic process-low versus -high activity in LUNG_NSCLC_LUAD.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUAD	MRPS9 →	+0.464	+0.709	<.001	.008	3	4
LUNG_SCLC	SGPP1 →	-0.564	-0.940	.004	<.001	3	4
BLOOD_Leukemia	TIMM9 →	+0.562	+0.810	<.001	.002	3	4
LUNG_NSCLC_LUAD	RSL1D1 →	+0.356	+0.609	.005	.002	3	3
KIDNEY	IDH1 →	+0.940	+0.874	<.001	.007	3	3
KIDNEY	GLDC →	-3.237	-1.155	<.001	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

MRPS9 by Regulation of secondary metabolic process activity — LUNG_NSCLC_LUAD

Explore this box plot interactively →