Regulation of secondary metabolic process

Across TCGA cell cohorts, RNA activity of the Regulation of secondary metabolic process pathway is significantly associated with the RNA expression of multiple genes, with the LUNG_NSCLC_LUAD cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are PLAU, PLCG2, and WNT7A, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of secondary metabolic process activity versus PLAU in LUNG_NSCLC_LUAD (Pearson r = 0.41).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUAD	PLAU →	+2.678	+0.926	.001	<.001	3	4
KIDNEY	PLCG2 →	+2.334	+1.644	.006	<.001	3	4
OESOPHAGUS	WNT7A →	+1.619	+1.160	<.001	<.001	3	4
LUNG_NSCLC_LUSC	PPIL4 →	-0.922	-1.819	<.001	<.001	3	4
PANCREAS	CBR4 →	-1.174	-1.874	.007	<.001	3	4
PANCREAS	ZNF665 →	+1.322	+1.544	.005	.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0043455 vs PLAU — LUNG_NSCLC_LUAD

Explore this scatter interactively →