Response to corticotropin-releasing hormone

Across TCGA patient cohorts, RNA activity of the Response to corticotropin-releasing hormone pathway is significantly associated with the RNA expression of multiple genes, with the UCEC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are ZNF41, DMAC2L, and EGLN3-AS1, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Response to corticotropin-releasing hormone activity versus ZNF41 in UCEC (Pearson r = -0.41).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	ZNF41 →	-0.376	-0.261	.001	.001	3	4
UCEC	DMAC2L →	-0.857	-0.222	.005	.006	3	3
UCEC	EGLN3-AS1 →	-1.483	-0.262	.001	.001	3	3
LUAD	VSIG8 →	-0.127	-0.532	.009	<.001	3	3
PDAC	RGS2 →	+1.896	+0.315	<.001	.007	3	3
PDAC	ZNF319 →	-0.404	-0.286	.007	.003	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0043435 vs ZNF41 — UCEC

Explore this scatter interactively →