Response to corticotropin-releasing hormone

Across TCGA pan-cancer cohorts, RNA activity of the Response to corticotropin-releasing hormone pathway is associated with patient survival in 20 of 34 cancer lineages. Pathway activity is summarized from the expression of its 5 member genes.

The strongest signal is observed in adrenocortical carcinoma (ACC), where higher Response to corticotropin-releasing hormone pathway activity is associated with poorer disease-free survival. In most high-consensus cancer types, elevated pathway activity shows an unfavorable survival association, although some cancer types, such as UVM and LIHC, show the opposite pattern, with higher activity associated with better survival.

ACC, UVM, and THCA are the cancer lineages in which this pathway most reproducibly stratifies patient survival.

Pathway-activity survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 represent the survival AUCs for the high- and low-pathway-activity groups, respectively. The group with the lower AUC is interpreted as having poorer survival. The reported p-values are derived from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
ACC	DFS	Median	All	0.504	0.794	<.001	129	view →
UVM	OS	Tertile	All	0.790	0.394	<.001	80	view →
THCA	OS	Median	All	0.902	0.981	.003	50	view →
LIHC	OS	Quartile	II,III,IV	0.861	0.563	.007	47	view →
KICH	OS	Median	All	1.000	0.700	.005	37	view →
KIRC	DFS	Tertile	All	0.846	0.779	.012	30	view →
LGG	DFS	Quartile	All	0.888	0.764	<.001	24	view →
LUSC	DFS	Tertile	All	0.269	0.432	.005	22	view →
DLBC	DFS	Median	II,III,IV	0.580	1.000	.013	19	view →
BRCA	OS	Tertile	All	0.601	0.501	.011	19	view →
PAAD	OS	Quartile	All	0.322	0.648	.003	18	view →
UCS	OS	Tertile	IV	0.176	0.783	.024	12	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 20 lineages.

GO:0043435–ACC (DFS)

Open the ACC breakdown →