Response to corticotropin-releasing hormone

Across TCGA cell cohorts, RNA activity of the Response to corticotropin-releasing hormone pathway is significantly associated with the RNA expression of multiple genes, with the CNS cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are EIF2S1, PCDH12, and NEMF, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, EIF2S1 grouped by Response to corticotropin-releasing hormone-low versus -high activity in CNS.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CNS	EIF2S1 →	-1.200	-1.517	<.001	<.001	3	5
LUNG_SCLC	PCDH12 →	+0.237	+0.946	.004	.009	3	4
CNS	NEMF →	-0.599	-0.922	<.001	.005	3	4
UPPER_AERODIGESTIVE_TRACT	PRSS16 →	+1.046	+0.273	.002	.003	3	3
UPPER_AERODIGESTIVE_TRACT	RAB11FIP4 →	+1.318	+0.317	<.001	<.001	3	3
UPPER_AERODIGESTIVE_TRACT	ARHGAP32 →	+1.273	+0.279	.001	.002	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

EIF2S1 by Response to corticotropin-releasing hormone activity — CNS

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