Negative regulation of MAPK cascade

Across TCGA patient cohorts, RNA activity of the Negative regulation of MAPK cascade pathway is significantly associated with the protein abundance of multiple proteins, with the GBM cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are PLEKHO2, GMIP, and LCP1, each associated with the pathway in up to 10 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Negative regulation of MAPK cascade activity versus PLEKHO2 in GBM (Pearson r = 0.58).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	PLEKHO2 →	+0.378	+0.044	<.001	<.001	3	10
GBM	GMIP →	+0.408	+0.039	<.001	<.001	3	9
GBM	LCP1 →	+0.756	+0.056	<.001	<.001	3	9
GBM	LCP2 →	+0.572	+0.053	<.001	<.001	3	9
OV	LIMD2 →	+0.558	+0.023	.007	<.001	3	9
GBM	LSP1 →	+0.559	+0.031	<.001	<.001	3	9

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0043409 vs PLEKHO2 — GBM

Explore this scatter interactively →