Negative regulation of MAPK cascade

Across TCGA cell cohorts, RNA activity of the Negative regulation of MAPK cascade pathway is significantly associated with the RNA expression of multiple genes, with the OVARY cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are PELI2, TCP11L2, and TOX3, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, PELI2 grouped by Negative regulation of MAPK cascade-low versus -high activity in OVARY.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OVARY	PELI2 →	+1.544	+0.170	.003	.003	3	5
OVARY	TCP11L2 →	+1.177	+0.201	.004	.001	3	4
PANCREAS	TOX3 →	+2.324	+0.184	<.001	<.001	3	4
PANCREAS	RASGEF1B →	+1.006	+0.181	.002	.005	2	5
PANCREAS	BCL2L11 →	+0.505	+0.115	.002	.009	3	4
LIVER	CMC4 →	-1.433	-0.151	.004	.007	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

PELI2 by Negative regulation of MAPK cascade activity — OVARY

Explore this box plot interactively →