Positive regulation of MAP kinase activity

Across TCGA cell cohorts, RNA activity of the Positive regulation of MAP kinase activity pathway is significantly associated with the RNA expression of multiple genes, with the LARGE_INTESTINE cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are CUL2, CAV1, and IL6ST, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, CUL2 grouped by Positive regulation of MAP kinase activity-low versus -high activity in LARGE_INTESTINE.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	CUL2 →	-0.699	-1.121	.007	.002	3	5
OVARY	CAV1 →	-2.085	-0.771	.005	.006	3	4
LUNG_NSCLC_LUAD	IL6ST →	-1.210	-0.901	.004	<.001	3	4
BREAST	RREB1 →	+0.752	+1.022	<.001	<.001	3	4
LUNG_NSCLC_LUAD	MICAL2 →	-1.452	-0.708	.001	<.001	3	4
LUNG_NSCLC_LUAD	JAK1 →	-0.879	-0.823	.001	.006	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

CUL2 by Positive regulation of MAP kinase activity activity — LARGE_INTESTINE

Explore this box plot interactively →