Skeletal muscle tissue regeneration

Across TCGA patient cohorts, RNA activity of the Skeletal muscle tissue regeneration pathway is significantly associated with the protein abundance of multiple proteins, with the LUAD cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are TOP2A_S1247, DDX47, and PUS7, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Skeletal muscle tissue regeneration activity versus TOP2A_S1247 in LUAD (Pearson r = -0.01).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUAD	TOP2A_S1247 →	+0.931	+0.043	<.001	<.001	3	6
COAD	DDX47 →	+0.259	+0.021	.002	.006	3	6
BRCA	PUS7 →	+0.399	+0.020	<.001	.005	3	6
LSCC	CLASP1 →	+0.332	+0.044	<.001	<.001	3	6
LSCC	GMPS →	+0.290	+0.032	.003	.001	3	6
BRCA	NOSTRIN →	-0.879	-0.029	<.001	<.001	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0043403 vs TOP2A_S1247 — LUAD

Explore this scatter interactively →