Regulation of protein binding

Across TCGA patient cohorts, RNA activity of the Regulation of protein binding pathway is significantly associated with the protein abundance of multiple proteins, with the CCRCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are SEPTIN4_S117, DOCK11, and CTHRC1, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of protein binding activity versus SEPTIN4_S117 in CCRCC (Pearson r = -0.10).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CCRCC	SEPTIN4_S117 →	+0.815	+0.036	<.001	<.001	3	6
UCEC	DOCK11 →	+0.494	+0.050	<.001	.004	3	6
COAD	CTHRC1 →	+1.024	+0.030	<.001	<.001	3	6
COAD	FHL3 →	+0.524	+0.025	<.001	.001	3	6
COAD	HIP1 →	+0.254	+0.022	.002	.002	3	6
COAD	ISLR →	+0.691	+0.028	<.001	<.001	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0043393 vs SEPTIN4_S117 — CCRCC

Explore this scatter interactively →