Negative regulation of DNA binding

Across TCGA cell cohorts, RNA activity of the Negative regulation of DNA binding pathway is significantly associated with the shRNA dependency of multiple genes, with the BREAST cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are KDM1A, NSF, and RTN4R, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, KDM1A grouped by Negative regulation of DNA binding-low versus -high activity in BREAST.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BREAST	KDM1A →	-0.383	-0.234	<.001	<.001	3	5
BONE	NSF →	+0.288	+0.348	.001	.007	3	5
BLOOD_Leukemia	RTN4R →	-0.239	-0.311	<.001	<.001	3	4
OVARY	VHLL →	+0.148	+0.447	.004	.006	3	4
SKIN	BANK1 →	-0.154	-0.270	<.001	.009	3	4
PANCREAS	MNT →	+0.140	+0.211	.005	.004	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

KDM1A by Negative regulation of DNA binding activity — BREAST

Explore this box plot interactively →