Negative regulation of DNA binding

Across TCGA cell cohorts, RNA activity of the Negative regulation of DNA binding pathway is significantly associated with the RNA expression of multiple genes, with the OVARY cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are C11orf95, MATN2, and SPINDOC, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Negative regulation of DNA binding activity versus C11orf95 in OVARY (Pearson r = 0.56).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OVARY	C11orf95 →	+1.267	+1.640	<.001	<.001	3	6
PANCREAS	MATN2 →	-2.116	-1.056	<.001	.004	3	5
BLOOD_Leukemia	SPINDOC →	+0.980	+0.539	<.001	.003	3	5
BLOOD_Leukemia	RAE1 →	+0.530	+0.443	.001	.008	3	5
LARGE_INTESTINE	OTUB1 →	+0.479	+0.992	<.001	.003	3	5
BLOOD_Leukemia	PATZ1 →	+0.701	+0.600	<.001	.002	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0043392 vs C11orf95 — OVARY

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