"Regulation of CD4-positive, alpha-beta T cell differentiation"

Across TCGA cell cohorts, RNA activity of the "Regulation of CD4-positive, alpha-beta T cell differentiation" pathway is significantly associated with the RNA expression of multiple genes, with the STOMACH cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are PARVB, KLF11, and PCLAF, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, PARVB grouped by "Regulation of CD4-positive, alpha-beta T cell differentiation"-low versus -high activity in STOMACH.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
STOMACH	PARVB →	+2.821	+1.183	.001	<.001	3	4
PANCREAS	KLF11 →	-0.954	-1.013	.004	.009	3	4
OESOPHAGUS	PCLAF →	+1.558	+1.107	.009	.003	3	4
PANCREAS	RAB38 →	+2.351	+1.242	.001	.002	3	3
SKIN	LDLR →	-1.536	-0.763	.001	<.001	3	3
KIDNEY	IDH1 →	+1.103	+1.371	.003	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

PARVB by "Regulation of CD4-positive, alpha-beta T cell differentiation" activity — STOMACH

Explore this box plot interactively →