"Regulation of CD4-positive, alpha-beta T cell differentiation"

Across TCGA cell cohorts, RNA activity of the "Regulation of CD4-positive, alpha-beta T cell differentiation" pathway is significantly associated with the RNA expression of multiple genes, with the LUNG_NSCLC_LUSC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are LGALS1, RAB25, and EMP3, each associated with the pathway in up to 11 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, "Regulation of CD4-positive, alpha-beta T cell differentiation" activity versus LGALS1 in LUNG_NSCLC_LUSC (Pearson r = 0.75).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUSC	LGALS1 →	+6.125	+0.476	.004	.005	3	11
LUNG_NSCLC_LUSC	RAB25 →	-6.116	-0.388	<.001	.001	3	9
LUNG_NSCLC_LUSC	EMP3 →	+5.730	+0.396	<.001	<.001	3	9
LUNG_NSCLC_LUSC	ILDR1 →	-1.655	-0.409	<.001	<.001	3	8
BLOOD_Lymphoma	NMT2 →	+1.377	+0.402	<.001	<.001	3	8
LUNG_NSCLC_LUSC	ZEB1 →	+2.943	+0.383	<.001	.001	2	9

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0043370 vs LGALS1 — LUNG_NSCLC_LUSC

Explore this scatter interactively →