Enucleate erythrocyte differentiation

Across TCGA patient cohorts, RNA activity of the Enucleate erythrocyte differentiation pathway is significantly associated with the protein abundance of multiple proteins, with the HNSC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are ATP7A, TJP3_S368, and TSPAN15, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Enucleate erythrocyte differentiation activity versus ATP7A in HNSC (Pearson r = -0.14).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
HNSC	ATP7A →	-0.151	-0.053	.002	.006	3	4
COAD	TJP3_S368 →	-0.366	-0.046	.001	.001	3	3
OV	TSPAN15 →	-0.377	-0.047	.006	.008	3	3
COAD	CLMN →	-0.288	-0.035	.002	.005	3	3
COAD	CTNND1 →	-0.227	-0.049	<.001	.001	3	3
COAD	MYH9_S1714 →	+0.341	+0.040	.004	.006	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0043353 vs ATP7A — HNSC

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