Enucleate erythrocyte differentiation

Across TCGA pan-cancer cohorts, RNA activity of the Enucleate erythrocyte differentiation pathway is associated with patient survival in 26 of 34 cancer lineages. Pathway activity is summarized from the expression of its 10 member genes.

The strongest signal is observed in uveal melanoma (UVM), where higher Enucleate erythrocyte differentiation pathway activity is associated with poorer disease-free survival. In most high-consensus cancer types, elevated pathway activity shows an unfavorable survival association, although some cancer types, such as READ and SCLC, show the opposite pattern, with higher activity associated with better survival.

UVM, READ, and LGG are the cancer lineages in which this pathway most reproducibly stratifies patient survival.

Pathway-activity survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 represent the survival AUCs for the high- and low-pathway-activity groups, respectively. The group with the lower AUC is interpreted as having poorer survival. The reported p-values are derived from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
UVM	DFS	Tertile	III,IV	0.207	0.866	<.001	85	view →
READ	OS	Quartile	All	1.000	0.419	<.001	68	view →
LGG	DFS	Median	All	0.625	0.840	<.001	51	view →
MESO	OS	Tertile	II,III,IV	0.320	0.767	.019	30	view →
SCLC	DFS	Tertile	III,IV	0.629	0.301	.008	27	view →
OV	OS	Tertile	All	0.788	0.895	.009	26	view →
UCS	OS	Tertile	IV	0.883	0.296	.024	24	view →
GBM	DFS	Quartile	All	0.545	0.216	.004	21	view →
DLBC	DFS	Tertile	All	0.603	0.944	.011	21	view →
KICH	OS	Quartile	II,III,IV	0.609	1.000	.011	17	view →
COAD	DFS	Quartile	III,IV	0.673	0.344	.004	17	view →
SKCM	DFS	Quartile	All	0.277	0.143	.010	15	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 26 lineages.

GO:0043353–UVM (DFS)

Open the UVM breakdown →