Enucleate erythrocyte differentiation

Across TCGA patient cohorts, RNA activity of the Enucleate erythrocyte differentiation pathway is significantly associated with the RNA expression of multiple genes, with the LUAD cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are GINS1, TRIP13, and BRCA1, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Enucleate erythrocyte differentiation activity versus GINS1 in LUAD (Pearson r = -0.04).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUAD	GINS1 →	+0.928	+0.236	<.001	<.001	3	7
GBM	TRIP13 →	+0.803	+0.814	<.001	<.001	3	7
GBM	BRCA1 →	+0.544	+0.619	<.001	<.001	3	7
GBM	GINS2 →	+0.803	+0.815	<.001	<.001	3	6
GBM	BRIP1 →	+0.914	+0.670	<.001	<.001	3	6
LUAD	NUF2 →	+0.935	+0.254	<.001	.005	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0043353 vs GINS1 — LUAD

Explore this scatter interactively →