Enucleate erythrocyte differentiation

Across TCGA cell cohorts, RNA activity of the Enucleate erythrocyte differentiation pathway is significantly associated with the RNA expression of multiple genes, with the UPPER_AERODIGESTIVE_TRACT cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are C19orf25, CFP, and MXD3, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, C19orf25 grouped by Enucleate erythrocyte differentiation-low versus -high activity in UPPER_AERODIGESTIVE_TRACT.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UPPER_AERODIGESTIVE_TRACT	C19orf25 →	+0.581	+1.407	.001	.001	3	4
LARGE_INTESTINE	CFP →	+0.418	+1.388	.004	.006	3	4
LARGE_INTESTINE	MXD3 →	+0.913	+1.318	.002	.001	3	4
BLOOD_Myeloma	LAMP1 →	+1.299	+1.317	.001	.005	3	4
PANCREAS	SLC10A3 →	-1.230	-1.611	.005	.001	3	3
UPPER_AERODIGESTIVE_TRACT	PTOV1 →	+0.901	+1.418	.004	.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

C19orf25 by Enucleate erythrocyte differentiation activity — UPPER_AERODIGESTIVE_TRACT

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