Enucleate erythrocyte differentiation

Across TCGA cell cohorts, RNA activity of the Enucleate erythrocyte differentiation pathway is significantly associated with the RNA expression of multiple genes, with the PANCREAS cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are CEBPG, NEMP1, and XPOT, each associated with the pathway in up to 16 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Enucleate erythrocyte differentiation activity versus CEBPG in PANCREAS (Pearson r = 0.57).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
PANCREAS	CEBPG →	+1.173	+0.220	<.001	<.001	3	16
STOMACH	NEMP1 →	+0.935	+0.110	<.001	<.001	3	14
LIVER	XPOT →	+0.998	+0.255	.001	.001	3	10
BONE	ID2 →	+2.965	+0.179	.001	.003	2	10
SOFT_TISSUE	KRAS →	+0.906	+0.201	<.001	<.001	3	8
OVARY	SPTLC1 →	+0.658	+0.159	<.001	<.001	3	8

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0043353 vs CEBPG — PANCREAS

Explore this scatter interactively →