Protein unfolding

Across TCGA patient cohorts, RNA activity of the Protein unfolding pathway is significantly associated with the RNA expression of multiple genes, with the OV cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are CYP2R1, OSBPL11, and PFKP, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Protein unfolding activity versus CYP2R1 in OV (Pearson r = -0.04).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OV	CYP2R1 →	-0.453	-0.088	.007	.006	3	4
PDAC	OSBPL11 →	-0.188	-0.070	<.001	<.001	3	4
COAD	PFKP →	+0.557	+0.111	.001	.008	3	4
LSCC	PIGS →	+0.480	+0.179	.002	<.001	3	4
BRCA	HIPK3 →	-0.522	-0.093	.004	.002	3	4
BRCA	NAF1 →	-0.438	-0.113	.003	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0043335 vs CYP2R1 — OV

Explore this scatter interactively →