Protein unfolding

Across TCGA cell cohorts, RNA activity of the Protein unfolding pathway is significantly associated with the RNA expression of multiple genes, with the SOFT_TISSUE cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are ITPR3, COA1, and LIPE, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Protein unfolding activity versus ITPR3 in SOFT_TISSUE (Pearson r = -0.61).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SOFT_TISSUE	ITPR3 →	-2.848	-0.088	<.001	.003	3	5
BLOOD_Leukemia	COA1 →	-0.982	-0.168	<.001	<.001	3	5
BLOOD_Lymphoma	LIPE →	-2.179	-0.143	<.001	.002	3	5
SOFT_TISSUE	DENND11 →	-1.009	-0.093	.009	.001	3	4
BLOOD_Leukemia	COQ2 →	+0.874	+0.132	.001	.002	3	4
LARGE_INTESTINE	WIPI1 →	-1.183	-0.123	<.001	.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0043335 vs ITPR3 — SOFT_TISSUE

Explore this scatter interactively →