Regulation of neutrophil degranulation

Across TCGA patient cohorts, RNA activity of the Regulation of neutrophil degranulation pathway is significantly associated with the RNA expression of multiple genes, with the UCEC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are PTAFR, LAPTM5, and CSF3R, each associated with the pathway in up to 8 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of neutrophil degranulation activity versus PTAFR in UCEC (Pearson r = 0.10).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	PTAFR →	+0.718	+0.705	<.001	<.001	3	8
UCEC	LAPTM5 →	+0.829	+0.974	.007	<.001	3	7
UCEC	CSF3R →	+1.036	+0.828	<.001	<.001	3	7
PDAC	PELATON →	+0.577	+0.249	.001	<.001	3	7
UCEC	AQP9 →	+1.184	+0.838	<.001	<.001	3	7
UCEC	MYO1F →	+0.564	+0.733	.001	.001	3	7

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0043313 vs PTAFR — UCEC

Explore this scatter interactively →