Regulation of neutrophil degranulation

Across TCGA cell cohorts, RNA activity of the Regulation of neutrophil degranulation pathway is significantly associated with the RNA expression of multiple genes, with the SKIN cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are C19orf53, VRK1, and ACYP1, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, C19orf53 grouped by Regulation of neutrophil degranulation-low versus -high activity in SKIN.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKIN	C19orf53 →	-0.791	-1.131	.001	.002	3	6
SOFT_TISSUE	VRK1 →	+0.911	+1.844	.006	.004	3	4
SOFT_TISSUE	ACYP1 →	+1.201	+2.061	.001	<.001	3	4
LUNG_NSCLC_LUSC	NDEL1 →	-0.824	-1.204	.002	<.001	3	4
SOFT_TISSUE	DYNC2H1 →	-1.453	-1.430	<.001	<.001	3	4
SOFT_TISSUE	FAM156A →	-1.275	-1.662	<.001	.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

C19orf53 by Regulation of neutrophil degranulation activity — SKIN

Explore this box plot interactively →