Neutrophil degranulation

Across TCGA patient cohorts, RNA activity of the Neutrophil degranulation pathway is significantly associated with the RNA expression of multiple genes, with the LSCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are SLA, SIRPB1, and LILRA1, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Neutrophil degranulation activity versus SLA in LSCC (Pearson r = -0.05).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	SLA →	+0.660	+0.305	<.001	<.001	3	7
HNSC	SIRPB1 →	+0.599	+0.199	.003	<.001	3	6
UCEC	LILRA1 →	+0.505	+0.404	<.001	.002	2	7
UCEC	CSF3R →	+1.233	+0.428	<.001	.001	3	6
HNSC	ITGAX →	+0.603	+0.186	<.001	<.001	3	6
LSCC	TMEM71 →	+0.641	+0.174	<.001	<.001	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0043312 vs SLA — LSCC

Explore this scatter interactively →