Neutrophil degranulation

Across TCGA cell cohorts, RNA activity of the Neutrophil degranulation pathway is significantly associated with the RNA expression of multiple genes, with the SKIN cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are EMC10, SNN, and TMEM89, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, EMC10 grouped by Neutrophil degranulation-low versus -high activity in SKIN.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKIN	EMC10 →	-1.160	-1.587	<.001	<.001	3	3
BLOOD_Myeloma	SNN →	-2.017	-1.824	.001	<.001	3	3
LARGE_INTESTINE	TMEM89 →	-0.312	-1.229	.001	.002	3	3
CNS	H2AC13 →	-1.076	-0.681	.002	.006	3	3
LUNG_SCLC	SLC26A6 →	-1.045	-0.738	.004	.004	3	3
SKIN	MKLN1 →	-0.584	-1.012	<.001	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

EMC10 by Neutrophil degranulation activity — SKIN

Explore this box plot interactively →