Eosinophil activation

pathway activity — cross-omics
GO:0043307Cross-omicsPROTEIN-MS → RNAPatientPairwise association · TCGA cohorts

Across TCGA patient cohorts, RNA activity of the Eosinophil activation pathway is significantly associated with the RNA expression of multiple genes, with the BRCA cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are HAUS3, CLOCK, and MCCD1P2, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.
LineagePartner geneX-scoreY-scorep(X)p(Y)Sampling consensusLineage consensus
BRCAHAUS3 →-0.258-0.103.005.00934
PDACCLOCK →-0.316-0.656.001<.00133
HNSCMCCD1P2 →+0.530+0.364<.001.00933
GBMRASL10B →-0.564-0.647<.001<.00124
PDACZDHHC15 →-0.329-0.727.004.00233
PDACMINDY2 →-0.508-0.761<.001.00133
Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

Exploration