Negative regulation of mast cell degranulation

Across TCGA patient cohorts, RNA activity of the Negative regulation of mast cell degranulation pathway is significantly associated with the protein abundance of multiple proteins, with the UCEC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are SKAP2, SPN, and STK10, each associated with the pathway in up to 9 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Negative regulation of mast cell degranulation activity versus SKAP2 in UCEC (Pearson r = 0.56).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	SKAP2 →	+0.608	+0.089	.001	<.001	3	9
PDAC	SPN →	+0.697	+0.050	<.001	.001	3	9
OV	STK10 →	+0.452	+0.073	<.001	.004	3	9
UCEC	WAS →	+0.608	+0.088	<.001	<.001	3	9
OV	WDFY4 →	+0.560	+0.075	.001	.001	3	9
HNSC	WIPF1 →	+0.361	+0.063	<.001	<.001	3	9

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0043305 vs SKAP2 — UCEC

Explore this scatter interactively →