Negative regulation of mast cell degranulation

Across TCGA cell cohorts, RNA activity of the Negative regulation of mast cell degranulation pathway is significantly associated with the RNA expression of multiple genes, with the BLOOD_Leukemia cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are RANBP9, ARFRP1, and TDP2, each associated with the pathway in up to 1 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Negative regulation of mast cell degranulation activity versus RANBP9 in BLOOD_Leukemia (Pearson r = -0.73).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	RANBP9 →	-0.854	-1.634	.004	.001	3	1
BLOOD_Leukemia	ARFRP1 →	-0.429	-1.265	.007	.004	3	1
BLOOD_Leukemia	TDP2 →	-0.545	-1.199	.008	.008	3	1
BLOOD_Leukemia	ERBIN →	-0.838	-1.199	.004	.008	3	1
BLOOD_Leukemia	FAM172A →	+0.490	+1.428	.004	<.001	3	1
BLOOD_Leukemia	TRAPPC13 →	-0.695	-1.714	.006	.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0043305 vs RANBP9 — BLOOD_Leukemia

Explore this scatter interactively →