Negative regulation of leukocyte degranulation

Across TCGA patient cohorts, RNA activity of the Negative regulation of leukocyte degranulation pathway is significantly associated with the RNA expression of multiple genes, with the LUAD cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are SBF2-AS1, RFC3, and HMGB1, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Negative regulation of leukocyte degranulation activity versus SBF2-AS1 in LUAD (Pearson r = -0.31).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUAD	SBF2-AS1 →	-0.307	-0.332	.002	.004	3	4
LSCC	RFC3 →	-0.569	-0.194	<.001	.001	3	4
LSCC	HMGB1 →	-0.416	-0.232	.002	.001	3	4
LSCC	LINC02273 →	+0.227	+0.142	<.001	.003	3	4
COAD	ARHGAP15 →	+0.439	+0.325	.002	.007	3	4
LSCC	XPO1 →	-0.313	-0.155	.002	.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0043301 vs SBF2-AS1 — LUAD

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