Leukocyte degranulation

Across TCGA cell cohorts, RNA activity of the Leukocyte degranulation pathway is significantly associated with the protein abundance of multiple proteins, with the OVARY cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are VAMP7, RAB14, and RAB5C, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Leukocyte degranulation activity versus VAMP7 in OVARY (Pearson r = 0.28).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OVARY	VAMP7 →	+1.290	+0.250	.001	<.001	3	6
BLOOD_Leukemia	RAB14 →	+0.428	+0.250	.003	<.001	3	6
LUNG_SCLC	RAB5C →	+0.623	+1.143	.003	<.001	3	6
LUNG_SCLC	LAMTOR3 →	+0.762	+0.891	.001	.002	3	6
SKIN	STXBP3 →	+1.089	+0.739	<.001	.001	3	5
BLOOD_Lymphoma	PTBP3 →	+0.559	+0.390	.001	.003	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0043299 vs VAMP7 — OVARY

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