Response to alkaloid

Across TCGA patient cohorts, RNA activity of the Response to alkaloid pathway is significantly associated with the protein abundance of multiple proteins, with the LUAD cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are XPO5, HEATR1, and C11orf96, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Response to alkaloid activity versus XPO5 in LUAD (Pearson r = 0.21).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUAD	XPO5 →	+0.429	+0.033	<.001	.008	3	7
LSCC	HEATR1 →	+0.296	+0.041	<.001	<.001	3	7
OV	C11orf96 →	-0.411	-0.019	.008	.002	3	7
CCRCC	COL14A1 →	-0.842	-0.033	<.001	<.001	3	7
PDAC	ESF1_S153 →	+0.834	+0.036	<.001	<.001	3	7
CCRCC	OLFML1 →	-0.950	-0.033	<.001	<.001	3	7

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0043279 vs XPO5 — LUAD

Explore this scatter interactively →