Response to alkaloid

Across TCGA patient cohorts, RNA activity of the Response to alkaloid pathway is significantly associated with the RNA expression of multiple genes, with the LUAD cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are HAS3, GLCCI1, and EEF1B2, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Response to alkaloid activity versus HAS3 in LUAD (Pearson r = -0.11).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUAD	HAS3 →	-0.887	-0.123	.004	.003	3	4
GBM	GLCCI1 →	+0.732	+0.165	.003	.004	3	4
CCRCC	EEF1B2 →	-0.285	-0.099	.003	.003	3	4
LUAD	SLC14A2 →	+1.241	+0.100	<.001	.002	3	4
GBM	LRRC27 →	+0.321	+0.127	.001	.007	3	4
GBM	CHST2 →	-0.634	-0.154	.004	.003	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0043279 vs HAS3 — LUAD

Explore this scatter interactively →