Response to alkaloid

Across TCGA cell cohorts, RNA activity of the Response to alkaloid pathway is significantly associated with the shRNA dependency of multiple genes, with the UPPER_AERODIGESTIVE_TRACT cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are BCL2L1, PILRB, and PFKFB3, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, BCL2L1 grouped by Response to alkaloid-low versus -high activity in UPPER_AERODIGESTIVE_TRACT.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UPPER_AERODIGESTIVE_TRACT	BCL2L1 →	-0.792	-0.199	<.001	<.001	3	7
BLOOD_Leukemia	PILRB →	+0.136	+0.253	.006	.002	3	6
BONE	PFKFB3 →	-0.128	-0.190	.007	.006	2	6
URINARY_TRACT	NUDT18 →	+0.350	+0.474	<.001	.003	3	5
SKIN	PRKAR1B →	-0.362	-0.245	<.001	<.001	3	5
CNS	USP28 →	+0.281	+0.185	.004	.004	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

BCL2L1 by Response to alkaloid activity — UPPER_AERODIGESTIVE_TRACT

Explore this box plot interactively →