Response to alkaloid

Across TCGA cell cohorts, RNA activity of the Response to alkaloid pathway is significantly associated with the RNA expression of multiple genes, with the SOFT_TISSUE cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are AIP, ANAPC1, and ZNF3, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, AIP grouped by Response to alkaloid-low versus -high activity in SOFT_TISSUE.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SOFT_TISSUE	AIP →	-0.817	-0.235	<.001	.001	3	5
URINARY_TRACT	ANAPC1 →	-1.047	-0.465	.002	.001	3	4
BLOOD_Leukemia	ZNF3 →	-0.941	-0.354	<.001	<.001	3	4
BLOOD_Leukemia	KARS1 →	-0.327	-0.246	.001	.001	3	4
BLOOD_Leukemia	PRR11 →	-1.421	-0.240	<.001	.004	3	4
BLOOD_Myeloma	GANAB →	-0.651	-0.282	.008	.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

AIP by Response to alkaloid activity — SOFT_TISSUE

Explore this box plot interactively →