Apoptotic cell clearance

Across TCGA patient cohorts, RNA activity of the Apoptotic cell clearance pathway is significantly associated with the protein abundance of multiple proteins, with the LSCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are GIMAP8, PLEKHO2, and PLEKHO2_T311, each associated with the pathway in up to 10 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Apoptotic cell clearance activity versus GIMAP8 in LSCC (Pearson r = 0.56).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	GIMAP8 →	+0.537	+0.088	<.001	<.001	3	10
UCEC	PLEKHO2 →	+0.455	+0.061	<.001	.005	3	10
LSCC	PLEKHO2_T311 →	+0.547	+0.073	<.001	<.001	3	10
LSCC	RCSD1 →	+0.537	+0.072	<.001	<.001	3	9
GBM	ARRB2 →	+0.383	+0.059	<.001	<.001	3	9
LSCC	SELL →	+0.515	+0.077	<.001	<.001	3	9

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0043277 vs GIMAP8 — LSCC

Explore this scatter interactively →