Apoptotic cell clearance

Across TCGA patient cohorts, RNA activity of the Apoptotic cell clearance pathway is significantly associated with the RNA expression of multiple genes, with the GBM cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are C5AR1, LILRB3, and CD36, each associated with the pathway in up to 8 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Apoptotic cell clearance activity versus C5AR1 in GBM (Pearson r = 0.35).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	C5AR1 →	+0.921	+0.177	.002	.001	3	8
GBM	LILRB3 →	+0.806	+0.119	<.001	.003	3	8
OV	CD36 →	+1.982	+0.195	<.001	<.001	3	7
LSCC	ANKRD1 →	+1.247	+0.161	<.001	<.001	3	7
OV	NRP1 →	+0.819	+0.125	<.001	<.001	3	7
LSCC	MEDAG →	+1.205	+0.173	<.001	<.001	3	7

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0043277 vs C5AR1 — GBM

Explore this scatter interactively →