Apoptotic cell clearance

Across TCGA cell cohorts, RNA activity of the Apoptotic cell clearance pathway is significantly associated with the RNA expression of multiple genes, with the LUNG_SCLC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are POLR1F, ITGAV, and HES6, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, POLR1F grouped by Apoptotic cell clearance-low versus -high activity in LUNG_SCLC.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_SCLC	POLR1F →	+0.863	+1.544	.001	<.001	3	5
LUNG_SCLC	ITGAV →	+1.706	+1.367	.001	<.001	3	5
LUNG_SCLC	HES6 →	-3.927	-1.186	<.001	.004	3	5
LUNG_SCLC	LATS2 →	+2.622	+1.200	<.001	<.001	3	5
LIVER	CSGALNACT2 →	+1.434	+1.317	.009	.003	3	5
LUNG_SCLC	CD151 →	+1.557	+1.046	<.001	.002	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

POLR1F by Apoptotic cell clearance activity — LUNG_SCLC

Explore this box plot interactively →