Apoptotic cell clearance

Across TCGA cell cohorts, RNA activity of the Apoptotic cell clearance pathway is significantly associated with the RNA expression of multiple genes, with the LUNG_NSCLC_LUSC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are EHD2, TGM2, and THBS1, each associated with the pathway in up to 16 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Apoptotic cell clearance activity versus EHD2 in LUNG_NSCLC_LUSC (Pearson r = 0.68).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUSC	EHD2 →	+4.442	+0.195	<.001	.003	3	16
PANCREAS	TGM2 →	+3.273	+0.133	<.001	.002	3	16
BONE	THBS1 →	+5.226	+0.230	<.001	<.001	3	15
BONE	P4HA2 →	+2.884	+0.211	<.001	<.001	3	15
BREAST	FN1 →	+4.730	+0.206	<.001	<.001	3	14
BONE	TGFBI →	+4.839	+0.197	<.001	<.001	3	14

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0043277 vs EHD2 — LUNG_NSCLC_LUSC

Explore this scatter interactively →