Apoptotic cell clearance

Across TCGA cell cohorts, RNA activity of the Apoptotic cell clearance pathway is significantly associated with the RNA expression of multiple genes, with the BREAST cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are ANXA1, PLEKHA2, and SERINC3, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Apoptotic cell clearance activity versus ANXA1 in BREAST (Pearson r = 0.57).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BREAST	ANXA1 →	+3.716	+0.322	<.001	<.001	3	7
BLOOD_Leukemia	PLEKHA2 →	+1.420	+0.253	.003	.009	3	6
SKIN	SERINC3 →	+0.465	+0.234	.003	.001	3	6
SOFT_TISSUE	SKAP2 →	+2.744	+0.310	<.001	.002	3	6
CNS	WDR18 →	-0.688	-0.376	.003	.003	2	7
LUNG_SCLC	CTRL →	-0.551	-0.217	.002	.005	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0043277 vs ANXA1 — BREAST

Explore this scatter interactively →