Positive regulation of monoatomic ion transport

Across TCGA cell cohorts, RNA activity of the Positive regulation of monoatomic ion transport pathway is significantly associated with the RNA expression of multiple genes, with the LUNG_NSCLC_LUSC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are GBP3, ALDH3B1, and HIF1A, each associated with the pathway in up to 9 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Positive regulation of monoatomic ion transport activity versus GBP3 in LUNG_NSCLC_LUSC (Pearson r = 0.82).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUSC	GBP3 →	+4.397	+0.430	<.001	<.001	3	9
LIVER	ALDH3B1 →	+3.218	+0.518	<.001	<.001	3	9
SOFT_TISSUE	HIF1A →	+1.505	+0.335	.006	<.001	3	9
LUNG_NSCLC_LUSC	SAMD9 →	+2.656	+0.367	.007	<.001	3	8
LIVER	APOL1 →	+5.530	+0.545	<.001	<.001	3	8
BONE	DDX60L →	+2.236	+0.386	.006	.009	2	9

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0043270 vs GBP3 — LUNG_NSCLC_LUSC

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