Telomere maintenance in response to DNA damage

Across TCGA cell cohorts, RNA activity of the Telomere maintenance in response to DNA damage pathway is significantly associated with the RNA expression of multiple genes, with the SKIN cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are GIT1, TONSL, and MCM7, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Telomere maintenance in response to DNA damage activity versus GIT1 in SKIN (Pearson r = 0.69).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKIN	GIT1 →	+0.928	+0.835	<.001	.005	3	5
BLOOD_Lymphoma	TONSL →	+0.835	+0.165	.003	<.001	3	5
BLOOD_Lymphoma	MCM7 →	+0.981	+0.162	.004	.001	3	5
BLOOD_Lymphoma	NLE1 →	+0.950	+0.161	<.001	<.001	3	5
SKIN	SMARCA4 →	+0.857	+0.711	.009	.006	3	4
SKIN	SLC25A22 →	+0.664	+0.769	.001	.008	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0043247 vs GIT1 — SKIN

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