Positive regulation of protein-containing complex disassembly

Across TCGA patient cohorts, RNA activity of the Positive regulation of protein-containing complex disassembly pathway is significantly associated with the RNA expression of multiple genes, with the LUAD cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are LINC01936, SVEP1, and RSU1P3, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Positive regulation of protein-containing complex disassembly activity versus LINC01936 in LUAD (Pearson r = 0.13).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUAD	LINC01936 →	+0.524	+0.529	.001	.008	3	5
LUAD	SVEP1 →	+0.821	+0.583	<.001	.002	3	5
CCRCC	RSU1P3 →	+0.665	+0.885	.001	.003	3	5
HNSC	ZNF781 →	+0.378	+0.862	<.001	.002	3	5
HNSC	ZNF582 →	+0.524	+0.915	<.001	.001	3	5
LUAD	ADAMTS9-AS2 →	+0.937	+0.707	<.001	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0043243 vs LINC01936 — LUAD

Explore this scatter interactively →