Positive regulation of protein-containing complex disassembly

Across TCGA pan-cancer cohorts, RNA activity of the Positive regulation of protein-containing complex disassembly pathway is associated with patient survival in 19 of 34 cancer lineages. Pathway activity is summarized from the expression of its 36 member genes.

The strongest signal is observed in small cell lung cancer (SCLC), where higher Positive regulation of protein-containing complex disassembly pathway activity is associated with better disease-free survival. In most high-consensus cancer types, elevated pathway activity shows an unfavorable survival association, although some cancer types, such as SCLC and ACC, show the opposite pattern, with higher activity associated with better survival.

SCLC, ACC, and HNSC are the cancer lineages in which this pathway most reproducibly stratifies patient survival.

Pathway-activity survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 represent the survival AUCs for the high- and low-pathway-activity groups, respectively. The group with the lower AUC is interpreted as having poorer survival. The reported p-values are derived from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
SCLC	DFS	Median	All	0.636	0.337	<.001	57	view →
ACC	OS	Median	III,IV	0.852	0.376	<.001	48	view →
HNSC	DFS	Tertile	II,III,IV	0.495	0.162	<.001	48	view →
LAML	DFS	Median	All	0.578	0.374	.007	42	view →
OV	OS	Tertile	III,IV	0.779	0.877	.005	28	view →
UCS	DFS	Tertile	IV	0.956	0.422	.024	24	view →
KIRC	OS	Tertile	All	0.721	0.562	.002	24	view →
KICH	OS	Median	III,IV	0.984	0.756	.019	20	view →
READ	DFS	Tertile	IV	0.298	0.695	.005	16	view →
CHOL	DFS	Median	IV	0.082	0.753	.008	13	view →
THYM	DFS	Quartile	All	1.000	0.581	.008	11	view →
SKCM	DFS	Quartile	All	0.242	0.161	.007	10	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 19 lineages.

GO:0043243–SCLC (DFS)

Open the SCLC breakdown →